Endocrine Abstracts

Introduction: In this present study, we assessed the effects of the last preoperative medical treatment (dopamine-agonists, somatostatin-analogous and GH receptor antagonists) on the proliferation parameters Ki-67 and Topoisomerase-IIα in pituitary adenomas of patients with acromegaly.Material and methods:: We retrospectively studied the clinical characteristics, neuroimaging, histology and immuno-histochemistry (Ki-67 and topoisomerase-IIα lab...

Introduction: GH and its receptor (GHR) are expressed in retinal ganglion cells (RGCs) in the eyes of chick embryos, and in mouse, rat and human eyes. Within the retina, exogenous GH has neuroprotective actions, mediated by caspase-dependent and caspase-independent mechanisms that may also be dependent upon IGF1 signaling. Conversely, the immunoneutralization of endogenous GH promotes apoptosis in the retina and in isolated RCGs. The functional relevance of retinal GH was furt...

The aims of this study are to assess the clinical characteristics of papillary and follicular thyroid cancer in young patients. We performed a retrospective analysis of 116 patient aged 20 years who underwent thyroidectomy and a mean follow-up of 11.1±0.6 years. There were 28 (24.1%) patients were classified into the residual cancer or relapse groups. Two of the 28 patients died of thyroid cancer. Thirteen patients who showed relapsed underwent 131I whole body scan; six o...